NEWS · RESEARCH · #247
SimpleDesign: a joint model proposed for protein sequence and structure co-design
The paper introduces SimpleDesign, a model intended to jointly model protein amino-acid sequences and three-dimensional structures to support co-design. It frames this approach as an alternative to common multi-stage pipelines that first train autoencoders to produce latent tokens and then train generative models on those latents.
KEY POINTS
- The paper introduces SimpleDesign, a model intended to jointly model protein amino-acid sequences and three-dimensional structures to support co-design.
- It frames this approach as an alternative to common multi-stage pipelines that first train autoencoders to produce latent tokens and then train generative models on those latents.
- Jointly modeling sequence and structure in a single model could simplify workflows and better capture the multi-modal relationship critical for protein engineering and drug discovery.
WHY IT MATTERS
Jointly modeling sequence and structure in a single model could simplify workflows and better capture the multi-modal relationship critical for protein engineering and drug discovery.