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COMPANY · ENTITY #26524

Exin Therapeutics

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EVENT TIMELINE

2

RESEARCH · 1 SOURCE · WIRED AI

Exin Therapeutics used an AI agent (Claude Sonnet 5) to perform a mouse brain injection

Exin Therapeutics founder Gabriel Ocana Santero reported using an AI agent to control a custom robotic surgical rig that selected a therapy and guided an injector to perform a live mouse brain injection; the team initially tested Anthropic’s Claude Opus 5.5 (which refused to inject) and then used Claude Sonnet 5. Safeguards included human approval of plans, an emergency motor cutoff, and restricted code access, but a coordinate-system glitch required a separate agent to modify code and delayed the procedure.

7.0

RESEARCH · 1 SOURCE · The Decoder

Claude Sonnet 5 agent autonomously selected and delivered gene therapy in a mouse

Researchers at Exin Therapeutics used Anthropic’s Claude Sonnet 5 to analyze a mouse epilepsy model, choose a gene therapy, pick a brain target and stereotactic coordinates, and control a motorized surgical rig to inject the treatment; a licensed veterinarian approved each irreversible step and the mouse reportedly recovered. Mid-procedure the agent refused to continue after detecting a calibration error, and more capable Claude models (Opus 5/5.5) had earlier declined to perform the live procedure; the work is described in an X thread and a technical report is expected but not yet peer-reviewed.

8.0