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Science (journal)

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3

RESEARCH · 1 SOURCE · TechCrunch AI

Microsoft’s MAI-DxO outperformed generalist doctors on simulated complex cases, study in Science

Microsoft published a Science paper reporting that its AI orchestration system MAI-DxO correctly diagnosed 83% of complex New England Journal of Medicine cases in a simulation, compared with 36% for individual generalist physicians using reference materials; specialists or physician teams (who typically handle such cases) were not included in the comparison. The study tested multiple base models (best results used OpenAI’s GPT-5 and GPT-5.5), found DxO added most value on complex cases and weaker models, and Microsoft said it will train a Mayo Clinic-backed healthcare foundation model and run real‑world evaluations at Beth Israel Deaconess.

8.0

RESEARCH · 1 SOURCE · The Verge AI

Microsoft’s Diagnostic Orchestrator (GPT-5) paper in Science reports higher diagnostic accuracy than doctors

Microsoft published a peer‑reviewed paper in Science describing Diagnostic Orchestrator, a multi‑agent medical AI system powered by OpenAI’s GPT‑5. In tests on case reports and emergency‑department data compiled into a new benchmark, SDBench, the system achieved substantially higher diagnostic accuracy than the human physicians in the study and lower estimated costs, though Microsoft and authors say clinical validation in real-world settings is still required.

8.0

RESEARCH · 1 SOURCE · The Decoder

DeepMind's AlphaProof Nexus (using Gemini 3.1 Pro) solved dozens of open math problems, Science paper

A DeepMind system called AlphaProof Nexus, built around Gemini 3.1 Pro and using the Lean proof assistant (and optionally the specialized AlphaProof tool), produced formal proofs that the authors report solved dozens of open problems: nine of 353 open Erdős problems (two unsolved for 56 years), 44 conjectures from the OEIS, an open question in algebraic geometry, and an improved bound in min-max optimization; the team shared solutions online and published a peer-reviewed paper in Science. DeepMind says the nine Erdős solutions were found even without the AlphaProof specialist tool.

9.0